| 2013 | Mary Sprague, A Little Wooden. Duane Reed Gallery, St. Louis |
| 2010 | Mary Sprague, Rhinoceros! Duane Reed Gallery, St. Louis |
| 2008 | Mary Sprague, Tree Drawings. Duane Reed Gallery, St. Louis (Catalog) |
| 2007 | Mary Sprague, Chickens! Duane Reed Gallery, St. Louis |
| 2006 | Mary Sprague, Chickens. Belloc-Lowndes Gallery, Chicago, IL |
| 2002-2003 | Mary Sprague, Drawings and Painting: 1960-2000. Retrospective Exhibition, Mitchell Museum, Mt. Vernon, IL (Organizing Institution), the Dubuque Museum of Art, Remington Museum, Ogdensburg, NY. (Catalog) |
| 1999 | Mary Sprague, Philosopher Stones. Sheldon Art Galleries, St. Louis |
| 1997 | Mary Sprague, Inside Animals. Elliot Smith Contemporary Art, St. Louis Invitational Artist Show: Fontbonne College Art Gallery |
| 1996 | Drawings and Paintings. Stauffacher Center, Sedalia, MO |
| 1994 | Paintings and Drawings. Elliot Smith Contemporary Art, St. Louis |
| 1993 | Paintings and Drawings. Elliot Smith Contemporary Art, St. Louis |
| 1992 | Large Drawings. Elliot Smith Contemporary Art, St. Louis |
| 1991 | New Drawings. Elliot Smith Gallery, St. Louis |
| 1990 | Paintings & Drawings. Elliot Smith Gallery, St. Louis |
| 1988 | Drawings. Bonsack Gallery, John Burroughs School, St. Louis |
| 1988 | New Work: Not About Horses. Elliot Smith Gallery, St. Louis |
| 1987 | New Work. Harwell Museum, Poplar Bluff, Missouri |
| 1985 | Roses and Other Wild Flowers. Wagman Gallery, St. Louis |
| 1985 | Looking for Mrs. Campbell. Fontbonne College, St. Louis |
| 1983 | Currents 21: St. Louis Art Museum, St. Louis. Curated by Jack Cowart |
| 1983 | Mary Sprague – Paintings. Klein Gallery, Chicago, IL |
| 1979 | My Best to the Family. St. Louis Community College at Meramec |
| 1977 | New Air-Brushed Stencil Paintings. Mark Twain BancShares Gallery |
| 1973 | New Work. St. Louis Community College at Meramec Art Gallery |
| 1972 | Mary Sprague: Exhibition. Michael Wyman Gallery, Chicago, IL |
| 1972 | How About the Cow Now? Martin Schweig Gallery, St. Louis |
| 1970 | Empty Chairs. St. Louis Community College at Meramec Art Gallery |
| 1968 | Paintings and Drawings. Martin Schweig Gallery, St. Louis |
| 1966 | Pen and Ink Drawings. Karamanducca Gallery, San Francisco |